Seagen

Senior Scientist, Conjugation Process Development

Technical Operations & Process Sciences - Bothell, Washington

Description

Summary

The Senior Scientist uses expert knowledge of scientific principles and concepts to serve as the single departmental point of contact, and demonstrates technical proficiency, scientific creativity, collaboration with others, and independent thought. They work on drug development problems of diverse scope by leveraging data analysis to identify innovative and practical solutions. They identify and champion new ideas and technologies that enhance business processes within functional area. They may lead an intra-department project or initiative involving other contributors. They may supervise the activities of more junior personnel and would be responsible for driving the development of those employees. They contribute toward peer reviewed publications, invention of IP, internal reports, and/or regulatory filings.

Principal Responsibilities:

• Leads pre-IND and/or late-stage antibody drug conjugate (ADC) development activities.
• May serve as functional area lead for clinical programs/inter-departmental initiatives.
• Leads significant components of drug development or technology projects.
• Independently designs, executes, and interprets multiple studies. Designs experiments to be carried out by others.
• Prepares lab and pilot scale antibody drug conjugates.
• Leads process characterization studies, risk assessment, and control strategy development for late-stage process development.
• Able to oversee multiple development projects, including early and late-stage programs.
• Applies practical and theory expertise of the relevant area of science, process development, and manufacturing.
• Demonstrates good knowledge of other functional areas in Process Sciences.
• Supports validation activities.
• Leverages literature, ICH/Regulatory guidance, and practical experience to perform their work and influence CMC strategies.
• Recommends and implements new technology that advances knowledge and productivity within department.
• Motivates and supports the career development and technical growth of direct reports. Regularly meets with, sets clear goals and expectations, and provides timely feedback to direct reports.
• Authors and reviews technical reports, manufacturing documents, regulatory submissions and publications.
• Presents at department, project team, and sr. management meetings. May present externally at scientific conferences.

Required Qualifications:

• B.S. and 14+ years; M.S. and 11+ years; Ph.D. and 3+ years of industry experience
• Degree in chemistry, biochemistry, chemical engineering, or related field
• Deep knowledge of antibody or protein production and/or conjugation processes
• Experience with GMP manufacturing and technology transfer to manufacturing sites
• Good understanding of analytical protein characterization (HPLC, IEF, CE-SDS)
• Willingness to work with highly potent cytotoxic molecules

Preferred Qualifications:

• Experience with ADC process development
• Direct experience with antibody or protein conjugation
• Proficiency with tangential flow filtration
• Experience with late-stage development
• Familiarity with CMC team function
• Strong knowledge of statistical software such as JMP
• Experience with programming languages such as Python, R, or SQL

As the leading employer in our industry in the Pacific Northwest, Seagen is proud to offer a competitive total compensation package as well as a comprehensive benefits program designed to support the whole lives of our employees and their families. Benefits include medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. To learn more about Seagen, please visit www.seagen.com.

Seagen is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by federal, state, or local law.

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Seagen

Seagen is an Equal Opportunity Employer

Submitted: 08/20/2021