Seagen
Research Associate III BioProcess Development (Purification)
Technical Operations & Process Sciences - Bothell, United States
Description
Seagen is a global, multi-product biotechnology company dedicated to developing and commercializing transformative cancer medicines. As the industry leader in antibody-drug conjugate (ADC) technology, we pioneered a new generation in the science of harnessing antibodies to deliver cell-killing agents directly to cancer cells. Seagen’s dedication to improving the lives of cancer patients goes beyond science, and we believe that every employee has a role in contributing to this mission. By working together with a shared dedication and diverse perspectives, we are able to reach our full potential and make a real difference in the world. Seagen is a fast-growing company and has an abundance of opportunities available for you to grow your career. Put your passion to work at Seagen and join us!
Summary:
The BioProcess Development Department at Seagen is seeking a Research Associate III to execute and lead purification process development efforts for antibodies, antibody-drug conjugates, and novel protein formats. The ideal candidate will have experience with a variety of chromatographic and filtration- based separation techniques, strong critical thinking skills, and an ability to design, execute, and draw conclusions from experimental studies. The ideal candidate should have good interpersonal skills and an ability to work effectively in cross-functional project teams. Candidates may be considered for this role at a lower or higher level, commensurate with experience.
Responsibilities:
- Lead purification process development efforts for new molecules from platform process fit assessment through IND submission
- Senior RAs and exceptional RA III level staff may serve as a CMC process lead, representing multiple DS/DP functions on the CMC core team
- Design and execute bench-scale chromatography and filtration development and characterization studies
- May contribute to risk-assessments and/or process characterization study design
- Coordinate (with the Material Generation Team) pilot-scale purifications to support team supply and toxicology batch manufacturing
- Transfer manufacturing processes to internal or external manufacturing facilities
- Lead and execute viral clearance validation studies supporting all phases of development
- Work with multiple functional areas and represent purification interests on cross-functional project and/or strategic initiative teams
- Author technical reports and regulatory filings
- Summarize and present data in group and project team meetings and contribute to discussions and decisions
Qualifications:
- A BS or MS degree in chemistry, engineering, biochemistry, biological sciences or a related discipline
- BS and 5+ years experience, MS and 2+ years experience
- Understanding of protein purification techniques and experimental design
- Experience with bioprocess technology development work is helpful
- Experience with design and execution of viral clearance validation studies is preferred
- Experience with technical transfer to GMP manufacturing sites is preferred
- Experience with AKTA systems and Unicorn software is desirable
- Strong organization, time management and problem-solving skills with attention to detail
- Team-oriented with good communication skills, desire to achieve team and individual goals
- Strong technical writing and presentation skills
As the leading employer in our industry in the Pacific Northwest, Seagen is proud to offer a competitive total compensation package as well as a comprehensive benefits program designed to support the whole lives of our employees and their families. Benefits include medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. To learn more about Seagen, visit www.seagen.com.
Seagen is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by federal, state, or local law.
To prevent the spread of COVID-19, and as an integral part of its public health and safety measures, Seagen requires that all newly-hired employees be fully vaccinated against COVID-19 before commencing employment, subject to reasonable accommodation and other requirements of applicable federal, state, and local law.
Apply:
Seagen
Seagen is an Equal Opportunity Employer
Submitted: 06/17/2022
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